An extended Tajima’s D neutrality test incorporating SNP calling and imputation uncertainties
نویسندگان
چکیده
منابع مشابه
M3: an improved SNP calling algorithm for Illumina BeadArray data
SUMMARY Genotype calling from high-throughput platforms such as Illumina and Affymetrix is a critical step in data processing, so that accurate information on genetic variants can be obtained for phenotype-genotype association studies. A number of algorithms have been developed to infer genotypes from data generated through the Illumina BeadStation platform, including GenCall, GenoSNP, Illuminu...
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MOTIVATION Most genotyping technologies for single nucleotide polymorphism (SNP) markers use standard clustering methods to 'call' the SNP genotypes. These methods are not always optimal in distinguishing the genotype clusters of a SNP because they do not take advantage of specific features of the genotype calling problem. In particular, when family data are available, pedigree information is i...
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Imputation is a commonly used technique that exploits linkage disequilibrium to infer missing genotypes in genetic datasets, using a well-characterized reference population. While there is agreement that the reference population has to match the ethnicity of the query dataset, it is common practice to use the same reference to impute genotypes for a wide variety of phenotypes. We hypothesized t...
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ژورنال
عنوان ژورنال: Statistics and Its Interface
سال: 2015
ISSN: 1938-7989,1938-7997
DOI: 10.4310/sii.2015.v8.n4.a4